We the to tell us which Grey's Anatomy moments are heartbreaking. Here are some of our favorite responses:

1.First, when "John Doe" wrote "007" on Meredith's hand, and she found out that he was actually George.

2.When Derek died after not being properly treated at a hospital.

3.And then, when Meredith had to explain to Zola and Bailey that Derek was dead.

4.When Denny died and Alex had to physically lift Izzie out of his hospital bed.

5.When Lexie finally told Mark how she felt but ended up dying a few episodes later.

6.And then, when Mark finally told Lexie he loved her right before she died.

7.When Mark died weeks after everyone was rescued.

8.When Cristina told Owen what happened in the woods after the plane crash.