Mary-Kate Olsen was willing to play Michelle Tanner in Fuller House, but Ashley didn't want to revive her acting career. Mary-Kate volunteered to take the role, but it ultimately boiled down to bad timing and scheduling conflicts. Despite efforts from the show's producers and cast, the Olsen twins did not appear on the series. The reason for their absence is similar to Michelle's absence in Fuller House, with Mary-Kate and Ashley mostly staying on the East Coast.

Both Stamos and Cameron-Bure confirmed that Mary-Kate was open to the idea, while Ashley wasn't keen on it.